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Tuesday, October 14, 2008
   
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THE EPIDEMIC
THEMES
 
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  CLINICAL MANAGEMENT
 
 
Introduction
Infection Control Precautions
Environmental Contamination
 
 
Introduction
 
Clinical management of HIV infection and AIDS is a part of comprehensive care for individuals affected by the disease. In order to meet the total needs of persons affected by the infection there are other facets of care like nursing care, counselling ad social support that have to be taken into consideration. To help meet these varied needs, the concept of comprehensive HIV/AIDS care across a continuum is advocated. This is the pooling together of medical and social services within the community, and the creation of linkages between the community care initiatives and all levels of the health care system.
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Infection Control Precautions
 
Universal Precautions
 
The Centers for Disease Control (CDC) developed universal precautions to prevent transmission of blood-borne pathogens. These precautions are designed to prevent direct contact with blood, body fluids, and certain other fluids (amniotic fluid, semen, vaginal fluid, cerebrospinal fluid, serial transudates/exudates, and inflammatory exudates). Recommended barrier precautions include the use of gloves for procedures, imparting a risk of contact with these potentially infected fluids, tissues, and materials; the use of masks and protective eyewear when splatter of such body fluids is anticipated; and the use of gowns or other protective garments when clothing is likely to be soiled.
 
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Body Substance Precautions

 

Body Substance Isolation (BSI) or Body Substance Precautions (BSP) is an alternative system of infection control, practiced by many institutions in which the decision about barrier protection is based on the degree
of anticipated contact with body fluids and tissues. Unlike universal precautions, which are based on the patient's diagnosis (disease specific), BSI is based on the degree of contact anticipated, regardless of diagnosis. In practice, the differences are largely semantic. Both universal precautions and BSI emphasise prevention of sharps injuries and use of barrier protection for avoiding exposure to potentially infectious materials. Neither requires the use of labeling of patients or specimens for implementation.
 
Standard Precautions
 
In 1996, the CDC announced an entirely new system of infection control. These standard precautions include features of both BSI and universal precautions and apply to all patients. They require the use of gloves, protective clothing, and other barriers as needed to prevent direct contact with all body fluids (except sweat).
 
Precautions for Preventing Needlestick Injuries
 
Needlestick injury is the most frequent cause of occupational HIV infection. Immediately after use, health care workers should discard needles and other sharp instruments in puncture-resistant containers. They must not resheath or otherwise manipulate used needles. Needles must never be placed on beds, furniture, or in waste cans. Puncture-resistant disposal containers should be located in emergency trauma rooms,on code-blue carts, in operating room suites, and in other areas as close as possible to the point of needle use. For the rare situation, in which needle recapping is necessary, health care workers should use a single-handed method (e.g., in which the needle cap is placed in a bracket, not held in one hand) or a recapping shield device (e.g., in which a shield device protects the hand holding the needle cap).
 
Sharp Disposals
 
Access to proper sharps disposal containers, located at the "point of needle use," can prevent many post-use sharps injuries. Use of these impervious containers also protects cleaning personnel, laundry workers, and trash handlers who are at risk for "downstream" injuries when needles are carelessly discarded or abandoned.
 
Needleless Devices
 
Safer needle devices, which are engineered to retract, cover, or blunt the needle after use, are now in widespread use. The most efficacious devices are passive (do not require an action on the part of the user to activate the safety feature), are readily implemented without extensive training, do not increase discomfort or complications in the patient, and are cost-effective. With proper training and experience, these new devices can help to prevent needle injuries, especially those that would occur after the needle was used for its intended purpose.
 
Needleless infusion systems are associated in some but not all studies with a reduction in the frequency of hollow-bore needle injuries. Although many needles used for intravenous infusions are not contaminated with blood, those at "downstream" sites, and those used for heparin flushes, are potentially hazardous. To the extent that the needleless systems eliminate this higher risk subset of contaminated needles, they should contribute to a true reduction in disease transmission. Moreover, it is difficult to determine if the needle is contaminated, and most injured heatlh care providers worry about the potential risk, even if the subjective data argue against a significant risk. Preventing this type of injury is also an important component of risk management.
 
Handwashing
Careful handwashing with soap and water is an essential component of infection control. Health care
workers should carefully wash their hands before and after each patient contact, after gloves are removed, and whenever contamination with potentially infective materials occurs.
 
Gloves

The CDC recommends using disposable protective gloves if the health care worker anticipates direct exposure to infected blood, secretions, excretions, other body fluids, or tissue specimens. Gloves may provide an extra margin of safety by preventing direct contact with body fluids, but they are no substitute for handwashing and needlestick precautions. Health care workers with exudative skin lesions, weeping dermatitis, or cutaneous wounds should not perform patient care activities until the condition resolves. Clinicians should wear two pairs of gloves (double-gloving) when performing invasive surgical procedures and whenever they expect prolonged contact with large amounts of blood. Workers with evidence of glove-induced dermatitis should wear hypoallergenic gloves. Gloves do not prevent needle injuries, but may reduce the volume of blood transmitted into the injury during an exposure.
 
Masks, Goggles, and Face Shields

Health care workers should wear masks and protective eyewear when anticipating splashes of blood or other body fluids. The CDC recommends routinely wearing masks and eyewear during airway manipulations and endoscopic or dental procedures. Using masks is also prudent in the presence of coughing patients, suspected of having contagious respiratory infection until diagnosis excludes these infections or until treatment renders them noncontagious. Clinicians should assign to private rooms those patients with contagious diseases, transmitted through the airborne route. Such patients should wear masks when leaving their hospital rooms.
 
Precautions for Preventing Spread of Tuberculosis
Co-infection with tuberculosis and HIV is a common problem in urban areas. Clinicians should suspect tuberculosis in immunosuppressed patients and other patients at epidemiological risk who present with symptoms or signs of pulmonary infection. The major cause of nosocomial and occupational outbreaks of tuberculosis is a failure to recognise that a patient is infectious, not a failure of infection control precautions. Ideally, patients with known or suspected active pulmonary tuberculosis should be placed in rooms engineered to enhance respiratory isolation. Ventilation should allow for at least six air exchanges per hour and be maintained at a negative pressure relative to other patient care areas. The doors and windows of rooms housing patients for whom tuberculosis precautions are in place should be kept closed. Infectious patients should leave the room only when necessary and should wear a mask. A properly tied standard surgical mask adequately minimises droplet dissemination from these patients; high-efficiency masks are not required. Clinicians should maintain the patient in respiratory isolation until diagnosis excludes tuberculosis or until treatment results in a clinical response and the patient is no longer infectious.
Persons in contact with patients with diagnosed or suspected pulmonary tuberculosis should wear a high-efficiency particulate respirator to minimise inhalation of particles in the size range of desiccated airborne tuberculosis bacteria. Use of these masks requires fitness testing, although the value of this requirement has not been established.
 
Laundry
 
Linens and hospital garments should be placed in impermeable bags and laundered using standard hospital procedures. Double-bagging is not necessary unless the outside of the bag is contaminated.
 
Waste Disposal
 
Contaminated disposable items should be placed in waterproof bags and disposed of in accordance with local ordinances. Before disposal, items saturated with body fluids, laboratory specimens, human and animal tissues, fluid-filled containers, and needles and other sharps should be decontaminated.
 
Sterilisation and Disinfection
 
Contaminated disposable items should be placed in waterproof bags and disposed of in accordance with local ordinances. Before disposal, items saturated with body fluids, laboratory specimens, human and animal tissues, fluid-filled containers, and needles and other sharps should be decontaminated.
 
Environmental Contamination
 
Environmental surfaces and fomites should be washed and disinfected with a mycobactericidal hospital disinfectant. A freshly made solution of 1/100 dilution of 5.25 percent sodium hypochlorite (household bleach) is an effective germicide. A 1/10 dilution should be used for heavily contaminated items, although bleach may damage some environmental surfaces. Spills should be cleaned up before disinfecting the surfaces; the presence of organic material reduces the efficacy of disinfection. Disinfectants may lose their potency if diluted too extensively or allowed to stand for longer than the manufacturer's recommended time.
 
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